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Pagoclone users post about their experiences…

Pagoclone users are posting about their personal experience with the drug.  It’s like data from the trenches…  (i.e., the real users themselves)

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  1. April 17th, 2009 at 10:11 | #1

    I got a call this week to participate! I can’t however, the closest site is 3 hours away, and you have to make 8 office visits. And they are not open on Saturdays. Oh well, science is just going to have to miss out on Pam’s take on this!

    [Reply]

    Greg @ Stuttering.me Reply:

    Yeah, I didn’t sign up for the trial–so who knows if I could have been a part of it. I’m really glad to see it happen, but I honestly don’t know if I would partake… I’m not sure what I would gain…

    [Reply]

  2. fithun
    April 27th, 2009 at 22:11 | #2

    i started the treatment two weeks backs and i have already started to see a big change in the way i speak.it is not about decreasing anxiety but the blocks have reduced dramatically.the blocks which used to be there when i am alone or wtih people is gone.if it is anxiety reducing agents i wouldn’t have seen block going away when i am alone and relaxing.i think this drug is a major break through in the treatment of stuttering.i really encourage anyone around the study areas to participate in those studies

    [Reply]

    Greg @ Stuttering.me Reply:

    Your experience is to be expected, if our understanding of the neurochemical mechanics are right. Pagoclone increases GABA, which is associated w/ a reduction in D2 production. We’ve known that it’s a relatively ineffective anti-anxiety medication for quite some time–so any anti-anxiety results is just an added benefit. The real juice comes from reducing D2 production (thereby reducing D2 uptake), thereby allowing the basal ganglia thalamo-cortical circuit to run more efficiently..

    Thanks so much for your comment; I hope you come back (often) and report your experiences!

    [Reply]

  3. ayann
    October 10th, 2009 at 06:51 | #3

    im a stutterer since i was a kid. I am unemployed for nearly two years. My stuttering problem is getting worse cant hardly speak specially during interviews and simple gathering even for common friends. I know I am talented person but I cant earn respect when i have to speak out. I am tired of pretending i am fluent and suffering from descrimination. Please help

    [Reply]

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